Scientific Impact

Publications

DNA Curtains technology has enabled high-impact research published in the world's leading scientific journals. The following publications demonstrate the breadth and rigor of insights the technology enables.

Published in Nature | Science | Molecular Cell | PNAS | Nucleic Acids Research | Cell Reports

DNA Damage Repair

Repair
Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair
Myler L. R. et al.  Molecular Cell  (2017)
Repair
DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP
Deshpande R. A. et al.  Science Advances  (2020)
Repair
Bloom helicase mediates formation of large single-stranded DNA loops during DNA end processing
Xue, C. et al.  Nature Communications  (2022)
Repair
Single-molecule visualization reveals the damage search mechanism for the human NER protein XPC-RAD23B
Cheon, N. Y. et al.  Nucleic Acids Research  (2019)

Motor Proteins

Motor
The promoter-search mechanism of Escherichia coli RNA polymerase is dominated by three-dimensional diffusion
Wang, F. et al.  Nature Structural & Molecular Biology  (2013)
Motor
The dynamics of eukaryotic replication initiation: origin specificity, licensing, and firing at the single-molecule level
Duzdevich, D. et al.  Molecular Cell  (2015)
Motor
Direct visualization of replication and R-loop collision using single-molecule imaging
Kim, S. et al.  Nucleic Acids Research  (2024)

DNA Binding & Nucleases

Nuclease
Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins
Myler, L. R. et al.  PNAS  (2016)
CRISPR
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
Sternberg, S. et al.  Nature  (2014)
CRISPR
Mechanism of Cas9 inhibition by AcrIIA11
Dillard, K. E. et al.  Nucleic Acids Research  (2025)
CRISPR
CRISPR-Guided Programmable Self-Assembly of Artificial Virus-Like Nucleocapsids
Calcines-Cruz, C. et al.  Nano Letters  (2021)

DNA & Chromatin Organization

Chromatin
Human cohesin compacts DNA by loop extrusion
Kim, Y. et al.  Science  (2019)
Chromatin
Single-Molecule Imaging Reveals a Collapsed Conformational State for DNA-Bound Cohesin
Stigler, J. et al.  Cell Reports  (2016)
Chromatin
Single-molecule imaging of DNA curtains reveals intrinsic energy landscapes for nucleosome deposition
Visnapuu, M. L. et al.  Nature Structural & Molecular Biology  (2009)
Chromatin
Telomere Recognition and Assembly Mechanism of Mammalian Shelterin
Erdel, F. et al.  Cell Reports  (2017)
Chromatin
Single-molecule imaging reveals a direct role of CTCF's zinc fingers in SA interaction and cluster-dependent RNA recruitment
Huber, J. et al.  Nucleic Acids Research  (2024)

Note: This list highlights representative publications. DNA Curtains technology was originally developed in the Greene Lab at Columbia University and has been used by research groups worldwide. If you have published work using DNA Curtains technology and would like it listed here, please contact us.

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